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Literature summary extracted from

  • Seagrave, J.; Reyes, P.
    Pyrimidine nucleoside monophosphate kinase from rat bone marrow cells: a kinetic analysis of the reaction mechanism (1987), Arch. Biochem. Biophys., 254, 518-525.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.14 ADP
-
 Rattus norvegicus
2.7.4.14 UDP product inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.14 0.067
-
 ATP pH 7.1, 37°C Rattus norvegicus
2.7.4.14 0.13
-
 CMP pH 7.1, 37°C Rattus norvegicus
2.7.4.14 0.35
-
 ATP pH 7.1, 37°C Rattus norvegicus
2.7.4.14 1.4
-
 UMP pH 7.1, 37°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.14 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.4.14 ATP + UMP = ADP + UDP reaction mechanism is sequential and nonequilibrium in nature, substrates bind to the enzyme in a random order, substrate binding is cooperative Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.14 bone marrow
-
 Rattus norvegicus
-